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Mathieu Bey

The Skin microbiota: a target for Next Generation active ingredients

The skin surface is composed of molecules derived from our skin cells, our environment and from the microorganisms living on our skin. The composition and the diversity of skin microorganisms are directly linked to parameters such as temperature, pH, humidity, lipid content and oxygen gradient. The characterization based on Omics tools (metagenomic, transcriptomic, proteomic…) has highlighted the microbiota as a unique ecosystem for each individual whose role in metabolic, immune and neurological functions is now well established [1].

Role of commensal species

One of the next challenges will be to understand more precisely the role of commensal species composing the skin microbiota. Multiple researches have shown that Propionibacterium acnes, newly called Cutibacterium acnes, comprised different phylotypes, some of them linked to acne pathogenicity. Recently, Nakatsuji et al. (2017) reports evidence that the community of bacteria residing on normal human skin provides protection against S. aureus. Subsequently, isolated S. hominis A9 strain from normal skin was used to produce a Sh-lantibiotics with selective and efficient activity against S. aureus [2].

Diversity and balance matter

The diversity of skin microbiota is associated to healthy skin when its value is high. In the case of psoriasis, a high-resolution shotgun metagenomics method was used to characterise the microbiome of psoriatic patients. Results showed decrease diversity and increase in Staphylococcus with potential strain-level variations as key determinants of the psoriatic microbiome [3]. An interesting comparative study between the microbiota of Yanomami indians and US citizens led to the conclusion that the Yanomami indians exhibited highest bacterial diversity and westernisation severely seems to affect human skin micro biome diversity [4].

The advanced research on skin microbiota exposed new challenges. The determination at the strain level of commensal species (Staphylococcus epidermis, C. acnes) could help to find new specific targets and solutions to restore the balance between microorganisms. If the balance of the skin microbiota and the diversity are complex to define, the lost of equilibrium must be prevent to keep microbial homeostasis. New active ingredients, taking into account the skin microbiota, can create or help to restore an environment for its protection and the protection of the skin.

M. Bey
(Biovitis, Le Bourg - 15400 Saint Etienne de Chomeil, France)
E. Filaire
(Greentech, Biopôle Clermont-Limagne 63360 Saint-Beauzire, France)
JY. Berthon
(Biovitis et Greentech)


Footnotes

[1] Grice EA. and Segre JA.: The skin microbiome. (2011) Nat Rev Microbiol. 9(4): 244–253.

[2] Nakatsuji T., Chen TH., Narala S., Chun KA., Two AM., Yun T., Shafiq F., Kotol PF., Bouslimani A., Melnik AV., Latif H., Kim JN., Lockhart A., Artis K., David G., Taylor P., Streib J., Dorrestein PC., Grier A., Gill SR., Zengler K., Hata TR., Leung DY., Gallo RL.: Antimicrobials from human skin commensal bacteria protect against Staphylococcus aureus and are deficient in atopic dermatitis. (2017) Sci Transl Med. 22; 9(378).

[3] Tett A., Pasolli E., Farina S., Truong DT., Asnicar F., Zolfo M., Beghini F., Armanini F., Jousson O., De Sanctis V., Bertorelli R., Girolomoni G., Cristofolini M., Segata N. : Unexplored diversity and strain-level structure of the skin microbiome associated with psoriasis. (2017) NPJ Biofilms Microbiomes. 22; 3:14.

[4] Clemente JC., Pehrsson EC., Blaser MJ., Sandhu K., Gao Z., Wang B., Magris M., Hidalgo G., Contreras M., Noya-Alarcón Ó., Lander O., McDonald J., Cox M., Walter J., Oh PL., Ruiz JF., Rodriguez S., Shen N., Song SJ., Metcalf J., Knight R., Dantas G., Dominguez-Bello MG. : The microbiome of uncontacted Amerindians (2015) Sci Adv. 3;1(3).

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about Mathieu Bey
Mathieu Bey

Dr Mathieu Bey obtained his Ph.D. in 2012 from the University of Aix-Marseille, in the field of Microbiology & Biotechnology. He realized his Ph.D. in collaboration with the first French pilot plant for second generation Bioethanol.

In 2012, he joined the company Arbiom as Project manager for enzyme engineering and production where he performed the conception of enzymatic cocktail for lignocellulose degradation.

Recently, he joined the Greentech group as R&D manager in microbiology for health and well-being at Biovitis - a company from Greentech group.

Greentech Biopôle Clermont-Limagne 63360 St Beauzire - France Tel : +33 4 73 33 99 00 greentech@greentech.fr www.greentech.fr

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